Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice

doi:10.1038/s41467-018-06946-z

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice
	Sun, MZ ; Hao, TT ; Li, XY ; Qu, AH ; Xu, LG ; Hao, CL ; Xu, CL ; Kuang, H
刊名	NATURE COMMUNICATIONS
	2018
卷号	9 期号:-页码:-
关键词	GOLD NANOPARTICLES LIVING CELLS MONITORING AUTOPHAGY RAMAN-SCATTERING LIVE CELLS IN-VIVO ATP PROBES NANOSTRUCTURES QUANTIFICATION
ISSN号	2041-1723
DOI	10.1038/s41467-018-06946-z
文献子类	期刊论文
英文摘要	The interactions between chiral nanomaterials and organisms are still challenging and mysterious. Here, a chiral nanodevice made of yolk-shell nanoparticles tetrahedron (UYTe), centralized with upconversion nanoparticles (UCNPs), was fabricated to induce autophagy in vivo. The proposed chiral nanodevice displayed a tunable circular dichroism (CD) signal when modified with different enantiomers of glutathione (GSH). Notably, UYTe showed significant chirality-dependent autophagy-inducing ability after D-GSH-modification because the enhanced oxidative stress and accumulation in living cell. The activation of autophagy resulted in the reduced intracellular CD intensity from the disassembly of the structure. The intracellular ATP concentration was simultaneously enhanced in response to autophagy activity, which was quantitatively bio-imaged with the upconversion luminescence (UCL) signal of the UCNP that escaped from UYTe. The autophagy effect induced in vivo by the chiral UYTe was also visualized with UCL imaging, demonstrating the great potential utility of the chiral nanostructure for cellular biological applications.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30904]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Jiangnan Univ, Sch Food Sci & Technol, Int Joint Res Lab Biointerface & Biodetect, Wuxi 214122, Jiangsu, Peoples R China 2.Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
推荐引用方式 GB/T 7714	Sun, MZ,Hao, TT,Li, XY,et al. Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice[J]. NATURE COMMUNICATIONS,2018,9(-):-.
APA	Sun, MZ.,Hao, TT.,Li, XY.,Qu, AH.,Xu, LG.,...&Kuang, H.(2018).Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice.NATURE COMMUNICATIONS,9(-),-.
MLA	Sun, MZ,et al."Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice".NATURE COMMUNICATIONS 9.-(2018):-.