Complex silica composite nanomaterials templated with DNA origami

doi:10.1038/s41586-018-0332-7

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Complex silica composite nanomaterials templated with DNA origami
	Liu, XG ; Zhang, F ; Jing, XX ; Pan, MC ; Liu, P ; Li, W ; Zhu, BW ; Li, J ; Chen, H ; Wang, LH
刊名	NATURE
	2018
卷号	559 期号:7715 页码:593-598
关键词	CRYSTAL NANOSCALE MOLECULES NANOFABRICATION NANOSTRUCTURE ORIENTATION ELASTICITY MECHANICS STRATEGY SHAPES
ISSN号	0028-0836
DOI	10.1038/s41586-018-0332-7
文献子类	期刊论文
英文摘要	Genetically encoded protein scaffolds often serve as templates for the mineralization of biocomposite materials with complex yet highly controlled structural features that span from nanometres to the macroscopic scale(1-4). Methods developed to mimic these fabrication capabilities can produce synthetic materials with well defined micro-and macro-sized features, but extending control to the nanoscale remains challenging(5,6). DNA nanotechnology can deliver a wide range of customized nanoscale two-and three-dimensional assemblies with controlled sizes and shapes(7-11). But although DNA has been used to modulate the morphology of inorganic materials(12,13) and DNA nanostructures have served as moulds(14,15) and templates(16,17), it remains challenging to exploit the potential of DNA nanostructures fully because they require high-ionic-strength solutions to maintain their structure, and this in turn gives rise to surface charging that suppresses the material deposition. Here we report that the Stober method, widely used for producing silica (silicon dioxide) nanostructures, can be adjusted to overcome this difficulty: when synthesis conditions are such that mineral precursor molecules do not deposit directly but first form clusters, DNA-silica hybrid materials that faithfully replicate the complex geometric information of a wide range of different DNA origami scaffolds are readily obtained. We illustrate this approach using frame-like, curved and porous DNA nanostructures, with one-, two- and three-dimensional complex hierarchical architectures that range in size from 10 to 1,000 nanometres. We also show that after coating with an amorphous silica layer, the thickness of which can be tuned by adjusting the growth time, hybrid structures can be up to ten times tougher than the DNA template while maintaining flexibility. These findings establish our approach as a general method for creating biomimetic silica nanostructures.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30880]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China 2.East China Normal Univ, Sch chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai, Peoples R China 3.Xiamen Univ, Pen Tung Sah Inst Micronano Sci & Technol, Xiamen, Peoples R China 4.Biodesign Inst, Ctr Mol Design & Biomimet, Tempe, AZ 85281 USA 5.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85281 USA 6.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk, Tianjin, Peoples R China 7.Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk, Tianjin, Peoples R China 8.Chinese Acad Sci, Biodesign Ctr, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 9.Fudan Univ, Dept Chem, Adv Mat Lab, Shanghai Key Lab Mol Catalysis & Innovat Mat,iChE, Shanghai, Peoples R China 10.Chinese Acad Sci, Univ Chinese Acad Sci, Div Phys Biol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Liu, XG,Zhang, F,Jing, XX,et al. Complex silica composite nanomaterials templated with DNA origami[J]. NATURE,2018,559(7715):593-598.
APA	Liu, XG.,Zhang, F.,Jing, XX.,Pan, MC.,Liu, P.,...&Fan, CH.(2018).Complex silica composite nanomaterials templated with DNA origami.NATURE,559(7715),593-598.
MLA	Liu, XG,et al."Complex silica composite nanomaterials templated with DNA origami".NATURE 559.7715(2018):593-598.