Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis

doi:10.1136/svn-2018-000228

	Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis
	Lyu, Jinhao 6; Ma, Ning 5; Tian, Chenglin 4; Xu, Feng 3; Shao, Hang 3; Zhou, Xin 1,2; Ma, Lin 6; Lou, Xin 6
刊名	STROKE AND VASCULAR NEUROLOGY
	2019-09-01
卷号	4 期号:3 页码:129-134
关键词	intracranial atherosclerotic disease arterial spin labeling post labeling delay high-resolution mri stroke mechanism
ISSN号	2059-8688
DOI	10.1136/svn-2018-000228
英文摘要	Background and purpose We investigated the baseline demographics of patients with severe unilateral atherosclerotic stenosis of the middle cerebral artery (MCA) using multimodal MRI and evaluated the haemodynamic impairments and plaque characteristics of patients who had a recurrent stroke. Materials and methods We retrospectively recruited consecutive patients with severe unilateral atherosclerotic MCA stenosis who underwent arterial spin labelling (ASL) with postlabelling delay (PLD) of 1.5 and 2.5 s, and vessel wall MRI. For each PLD, cerebral blood flow (CBF) maps were generated. Hypoperfusion volume ratio (HVR) from 2 PLD CBF was calculated. An HVR value >= 50% was considered as severe HVR. Plaque areas, plaque burden, plaque length and remodelling index were measured. Plaque enhancement at maximal lumen narrowing site were graded. Baseline clinical and imaging characteristics were compared between patients with (event+) and without (event-) 1 year ischaemic events. Results Forty-three patients (47.23 +/- 12.15 years; 28 men) were enrolled in this study. Seven patients had an HVR >= 50%. During the 1-year follow-up, 7 patients had experienced a recurrent stroke. HVR were significantly higher in the event+ than event- (53.17%+/- 29.82% vs 16.9%+/- 15.57%, p=0.0002), whereas no significant difference was detected in plaque areas, plaque burden, remodelling index, plaque length and plaque enhancement grade. The multivariable analysis revealed that a severe HVR was significantly associated with a recurrent stroke (Odds ratio=12.93, 95% confidence interval 1.57 to 106.24, p=0.017) after adjusted by hypertension and smoking. Conclusion HVR obtained from two PLD ASL may be a useful imaging predictor of recurrent stroke.
资助项目	National Natural Science Foundation of China[:81825012] ; National Natural Science Foundation of China[81730048] ; National Natural Science Foundation of China[81671126] ; National Natural Science Foundation of China[81471390]
WOS关键词	ACUTE ISCHEMIC-STROKE ; ATHEROSCLEROSIS ; HYPOPERFUSION ; ENHANCEMENT ; PREVALENCE ; MECHANISMS ; RISK
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	BMJ PUBLISHING GROUP
WOS记录号	WOS:000489247700004
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/21453]
专题	中国科学院武汉物理与数学研究所
通讯作者	Lou, Xin
作者单位	1.Univ ChineseAcad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China 3.Tsinghua Univ, Automat Dept, Beijing, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing, Peoples R China 5.Capital Med Univ, Beijing Inst Brain Disorders, Dept Intervent Neurol, Ctr Stroke,China Natl Clin Res Ctr Neurol Dis,Bei, Beijing, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lyu, Jinhao,Ma, Ning,Tian, Chenglin,et al. Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis[J]. STROKE AND VASCULAR NEUROLOGY,2019,4(3):129-134.
APA	Lyu, Jinhao.,Ma, Ning.,Tian, Chenglin.,Xu, Feng.,Shao, Hang.,...&Lou, Xin.(2019).Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis.STROKE AND VASCULAR NEUROLOGY,4(3),129-134.
MLA	Lyu, Jinhao,et al."Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis".STROKE AND VASCULAR NEUROLOGY 4.3(2019):129-134.