Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria

doi:10.1021/acs.joc.9b01723

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria
	Zhang, Zhi-Jun 1; Wang, Chen2 ; Wu, Xing-De 1; Huang, Yan 2; Zhou, Wen-Xia 2; Zhao, Qin-Shi1
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2019-09-06
卷号	84 期号:17 页码:11301-11305
ISSN号	0022-3263
DOI	10.1021/acs.joc.9b01723
通讯作者	Zhou, Wen-Xia(zhouwx@bmi.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
英文摘要	Phlegmadine A (1), a Lycopodium alkaloid with a unique cyclobutane ring and featuring a complex tetracyclo-[4.2.2.0(3,8).0(3,10)]decane-bridged system, together with three biogenetically related known compounds, was isolated from the Phlegmariurus phlegmaria. The structures and absolute configurations of 1 and 2 were determined by NMR and single-crystal X-ray analysis. Among them, compound 2 exhibited noticeable protective effects for long-term potentiation impairment by corticosterone induced in mice. Moreover, we succeeded in the efficient synthesis of 1 from 3 by a biomimetic synthesis method.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000485089200077
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/69460]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhou, Wen-Xia; Zhao, Qin-Shi
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,et al. Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(17):11301-11305.
APA	Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,Huang, Yan,Zhou, Wen-Xia,&Zhao, Qin-Shi.(2019).Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria.JOURNAL OF ORGANIC CHEMISTRY,84(17),11301-11305.
MLA	Zhang, Zhi-Jun,et al."Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria".JOURNAL OF ORGANIC CHEMISTRY 84.17(2019):11301-11305.