A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis

doi:10.1039/c9qo00742c

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis
	Guo, Xiaowei 2,3,4; Wang, Jidong 1; Su, Can 3,4; Liu, Chongxi 2,3,4; Ma, Xiao-Yan 3,4; Yu, Zhiyin 2,3,4; Li, Jiansong 1; Wang, Xiangjing 2; Xiang, Wensheng 2; Huang, Sheng-Xiong3,4
刊名	ORGANIC CHEMISTRY FRONTIERS
	2019-09-21
卷号	6 期号:18 页码:3215-3219
ISSN号	2052-4129
DOI	10.1039/c9qo00742c
通讯作者	Xiang, Wensheng(xiangwensheng@neau.edu.cn) ; Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn)
英文摘要	Chemical investigation of a soil actinomycete strain Streptomyces gamaensis NEAU-Gz11 led to the isolation of three alkaloids 1-3 with antiviral activity. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compound 1 possesses a new and unique spiro-beta-triazinedione-gamma-hydantoin skeleton. The racemic feature and the chemical conversion experiments led us to propose a biosynthetic pathway for 1. Compound 1 (100 mg L-1) showed a strong anti-TMV (tobacco mosaic virus, TMV) activity on the host plants of tomatoes and peppers with inhibition rates of 72.34% and 62.09%, respectively.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000484960000003
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68774]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Xiang, Wensheng; Huang, Sheng-Xiong
作者单位	1.Zhejiang Hisun Pharmaceut Co Ltd, Zhejiang Key Lab Antifungal Drugs, Taizhou 318000, Peoples R China 2.Northeast Agr Univ, Heilongjiang Prov Key Lab Agr Microbiol, 59 Mucai St, Harbin 150030, Heilongjiang, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Guo, Xiaowei,Wang, Jidong,Su, Can,et al. A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3215-3219.
APA	Guo, Xiaowei.,Wang, Jidong.,Su, Can.,Liu, Chongxi.,Ma, Xiao-Yan.,...&Huang, Sheng-Xiong.(2019).A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis.ORGANIC CHEMISTRY FRONTIERS,6(18),3215-3219.
MLA	Guo, Xiaowei,et al."A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3215-3219.