Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces

doi:10.1021/acs.jnatprod.9b00022

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	Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces
	He, Xin 1,2; Wang, Yongjiang 2; Luo, Rong-Hua 3; Yang, Liu-Meng 3; Wang, Li 2; Guo, Dale 1; Yang, Jing2 ; Deng, Yun 1; Zheng, Yong-Tang 3; Huang, Sheng-Xiong2
刊名	JOURNAL OF NATURAL PRODUCTS
	2019-07-01
卷号	82 期号:7 页码:1813-1819
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.9b00022
通讯作者	Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn)
英文摘要	Eight new sulfur-bridged pyranonaphthoquinone (PNQ) dimers, naquihexcins C-J (1-8), a new PNQ monomer, naquihexcin K (10), and three known analogues (9, 11, and 12) were isolated from Streptomyces sp. KIB3133. The new structures were elucidated by interpretation of spectroscopic data. Dimer 4 was synthesized via a cascade S(N)2 reactions between two monomers and sodium sulfide, an approach motivated by the proposed biosynthetic pathway of dimeric pyranonaphthoquinones. Naquihexcin E (3) exhibited moderate HIV-1 inhibitory activity. Naquihexcins C (1), E (3), and I (7) showed inhibitory effects against two tumor cell lines (HL-60 and MCF-7) with IC50 values ranging from 1.4 to 16.1 mu M.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000477917800010
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68184]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Huang, Sheng-Xiong
作者单位	1.Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Sichuan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	He, Xin,Wang, Yongjiang,Luo, Rong-Hua,et al. Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(7):1813-1819.
APA	He, Xin.,Wang, Yongjiang.,Luo, Rong-Hua.,Yang, Liu-Meng.,Wang, Li.,...&Huang, Sheng-Xiong.(2019).Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,82(7),1813-1819.
MLA	He, Xin,et al."Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 82.7(2019):1813-1819.