New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network

	New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network
	Zhou KC 1,2; Liu MX 1,2; Cao Y*1; caoy@mail.kiz.ac.cn
刊名	Frontiers in Molecular Biosciences
	2017
卷号	4 期号:X 页码:e46
关键词	Cancer Mirna Function Oncogenes OncoGene–microrna–tumor Suppressor Gene Network Tumor Suppressor Genes
英文摘要	Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene-miRNA-TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene-miRNA-TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene-miRNA-TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer.
语种	英语
资助机构	This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617).
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11949]
专题	昆明动物研究所_分子病理学
通讯作者	caoy@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Zhou KC,Liu MX,Cao Y*,et al. New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network[J]. Frontiers in Molecular Biosciences,2017,4(X):e46.
APA	Zhou KC,Liu MX,Cao Y*,&caoy@mail.kiz.ac.cn.(2017).New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.Frontiers in Molecular Biosciences,4(X),e46.
MLA	Zhou KC,et al."New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network".Frontiers in Molecular Biosciences 4.X(2017):e46.