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	Solid-phase binding assay system and method for interferometrically measuring analytes bound to an active receptor
	ALLEN, JIMMY D.; COBB, MICHAEL E.; GUSTAFSON, ERIC K
	1995-01-24
著作权人	FIRST MEDICAL, INC.
专利号	AU1994073172A1
国家	澳大利亚
文献子类	发明申请
其他题名	Solid-phase binding assay system and method for interferometrically measuring analytes bound to an active receptor
英文摘要	Apparatus (10) and method for detecting and measuring analyte in biological and other sample solutions. A substrate (20) is provided with at least one active region which specifically binds analyte and an inactive region that does not, and a change in optical path length through the active region due to binding of analyte is measured. The substrate (20) is inserted into one or both beams of an interferometer (10) and moved relative to the interferometer (10). As the substrate (20) moves, the active and inactive regions pass successively through the beam(s) causing a periodic phase shift in the light. When the beams, one or both of which have undergone phase modulation, are recombined with each other, the phase modulation is converted into an amplitude modulation. Each recombined beam is directed to a photodetector (42, 45), which converts the periodically varying optical power into a periodically varying electrical signal. This signal has an amplitude proportional to the amount of bound analyte on the surface of the substrate (20) and a signal frequency equal to that at which the active regions move past the beam(s) in the interferometer (10). Servo control (60, 62, 65) is used to maintain the interferometer at a desired operating point that maximizes the sensitivity and linearity of the system so that the small phase differences due to analyte binding can be measured more accurately.
公开日期	1995-01-24
申请日期	1994-06-24
状态	失效
内容类型	专利
源URL	[http://ir.opt.ac.cn/handle/181661/62439]
专题	半导体激光器专利数据库
作者单位	FIRST MEDICAL, INC.
推荐引用方式 GB/T 7714	ALLEN, JIMMY D.,COBB, MICHAEL E.,GUSTAFSON, ERIC K. Solid-phase binding assay system and method for interferometrically measuring analytes bound to an active receptor. AU1994073172A1. 1995-01-24.

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