Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production

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	Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production
	Yan Y(闫岩) ; ZHANG LIHAN ; ITO TAKUYA ; Ju XD(瞿旭东) ; ASAKAWA YOSHINORI ; AWAKAWA TAKAYOSHI ; ABE IKURO ; Liu W(刘文)
刊名	Org. Lett.
	2012
卷号	14 期号:16 页码:4142-4145
ISSN号	1523-7060
其他题名	Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production
通讯作者	瞿旭东 ; 刘文
英文摘要	We herein report comparative analysis of two versions of the biosynthetic gene clusters of antimycins, a natural product family possessing up to 44 distinct entities. The biosynthetic pathway of antimycins is amenable to the high structural variation of the substrates, supported by successes in heterologous expression of the ant cluster and in fluorine incorporation. The latter facilitated the investigation of the structure-activity relationship into the usually invariable 3-formamidosalicylic acid moiety of the molecules.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ol301785x
语种	英语
WOS记录号	WOS:000307526900028
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28559]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Yan Y,ZHANG LIHAN,ITO TAKUYA,et al. Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production[J]. Org. Lett.,2012,14(16):4142-4145.
APA	闫岩.,ZHANG LIHAN.,ITO TAKUYA.,瞿旭东.,ASAKAWA YOSHINORI.,...&刘文.(2012).Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production.Org. Lett.,14(16),4142-4145.
MLA	闫岩,et al."Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production".Org. Lett. 14.16(2012):4142-4145.