Total Synthesis of Akuammiline Alkaloid (-)-Vincorine via Intramolecular Oxidative Coupling | |
Zi WW(资伟伟) ; Xie WQ(谢卫青) ; Ma DW(马大为) | |
刊名 | J. Am. Chem. Soc.
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2012 | |
卷号 | 134期号:22页码:9126-9129 |
ISSN号 | 0002-7863 |
其他题名 | 经由分子内氧化偶联对Akuammiline生物碱(-)-Vincorine的全合成 |
通讯作者 | 马大为 |
英文摘要 | An asymmetric total synthesis of the Akuammiline alkaloid (-)-vincorine (18 steps from 5-methoxytryptamine, 5% overall yield) is described. The key steps include Pd-catalyzed direct C-H functionalization of indole derivatives, organocatalyzed asymmetric Michael addition of aldehydes to alkylidene malonates, and intramolecular oxidative coupling between indole and malonate moieties. |
学科主题 | 生命有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1021/ja303602f |
语种 | 英语 |
WOS记录号 | WOS:000304837800027 |
公开日期 | 2013-08-23 |
内容类型 | 期刊论文 |
源URL | [http://202.127.28.38/handle/331003/28503] ![]() |
专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
推荐引用方式 GB/T 7714 | Zi WW,Xie WQ,Ma DW. Total Synthesis of Akuammiline Alkaloid (-)-Vincorine via Intramolecular Oxidative Coupling[J]. J. Am. Chem. Soc.,2012,134(22):9126-9129. |
APA | 资伟伟,谢卫青,&马大为.(2012).Total Synthesis of Akuammiline Alkaloid (-)-Vincorine via Intramolecular Oxidative Coupling.J. Am. Chem. Soc.,134(22),9126-9129. |
MLA | 资伟伟,et al."Total Synthesis of Akuammiline Alkaloid (-)-Vincorine via Intramolecular Oxidative Coupling".J. Am. Chem. Soc. 134.22(2012):9126-9129. |
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