Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols

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	Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols
	Liu ZJ(刘振江) ; Zhang F(张帆) ; Liu JT(刘金涛)
刊名	J. Fluor. Chem.
	2012
卷号	133 页码:102-107
ISSN号	0022-1139
其他题名	手性N-亚磺酰酮亚胺与α,β-不饱和三氟甲基酮的区域和立体选择性aldol反应
通讯作者	刘金涛
英文摘要	Regiospecific and diastereoselective aldol type reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones was reported, which affords the corresponding tertiary trifluoromethyl allylic carbinols in high yields with good diastereoselectivities (dr up to 90:10). The reduction of the condensation product 3a with LiBHEt3 and Catecholborane provides CF3-substituted syn- and anti-1,3-amino alcohols 5a and 5b in high yields with excellent diastereoselectivities (dr > 99:1). (C) 2011 Elsevier B.V. All rights reserved.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.jfluchem.2011.09.002
语种	英语
WOS记录号	WOS:000300469500015
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28303]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Liu ZJ,Zhang F,Liu JT. Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols[J]. J. Fluor. Chem.,2012,133:102-107.
APA	刘振江,张帆,&刘金涛.(2012).Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols.J. Fluor. Chem.,133,102-107.
MLA	刘振江,et al."Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with alpha,beta-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols".J. Fluor. Chem. 133(2012):102-107.