Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 中科院有机氟化学重点实验室

	Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system
	Zhang CP(张成潘) ; Chen QY(陈庆云) ; Guo Y(郭勇) ; Xiao JC(肖吉昌) ; Gu YC(顾玉诚)
刊名	Chem. Soc. Rev.
	2012
卷号	41 期号:12 页码:4536-4559
ISSN号	0306-0012
其他题名	经由亚磺化脱卤的氟烷基化反应进展
通讯作者	郭勇 ; 肖吉昌
英文摘要	The sulfinatodehalogenation reaction represents one of the most important methodologies to incorporate fluorine into organic molecules. Using inexpensive sulfur-containing reactants such as Na2S2O4 under mild conditions, per-and polyfluoroalkyl halides (RFX, X = Br, I, CCl3) can be transformed smoothly into the corresponding sulfinate salts. This method is also used for the perfluoroalkylation of alkenes, dienes, alkynes and aromatics. Notably, after 1998, the sulfinatodehalogenation of perfluoroalkyl chlorides (RFCl) has been realized by using dimethylsulfoxide (DMSO) as a solvent instead of CH3CN/H2O in the Na2S2O4/NaHCO3 initiation system. Perfluoroalkyl chlorides, ethyl chlorofluoroacetates and chlorodifluoroacetates, and even nonfluorinated compounds, such as ethyl chloro-or dichloroacetates and chloroform, were either converted into the corresponding sulfinate salts or alkylated alkenes, alkynes and aromatics (including porphyrins). The sulfinatodehalogenation reaction has remarkable advantages. With the increasing demands to utilize the unique properties of fluorine and fluorinated functional groups in medicinal, agricultural and material sciences, we believe that there will continue to be useful developments in sulfinatodehalogenation chemistry and it will be applied more widely in the future.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c2cs15352a
语种	英语
WOS记录号	WOS:000304555700009
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28293]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Zhang CP,Chen QY,Guo Y,et al. Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system[J]. Chem. Soc. Rev.,2012,41(12):4536-4559.
APA	张成潘,陈庆云,郭勇,肖吉昌,&顾玉诚.(2012).Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system.Chem. Soc. Rev.,41(12),4536-4559.
MLA	张成潘,et al."Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system".Chem. Soc. Rev. 41.12(2012):4536-4559.