Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate

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	Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate
	Yang J(杨洁) ; Min QQ(闵巧桥) ; HE YI ; Zhang XG(张新刚)
刊名	Tetrahedron Lett.
	2011
卷号	52 期号:36 页码:4675-4677
ISSN号	0040-4039
其他题名	通过苄基锌试剂对手性三氟丙酮酸酯亚胺高立体选择性加成合成具有季碳手心的a-氨基酸
通讯作者	张新刚
英文摘要	An effective and facile method for highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids was developed in good yields with high diastereoselectivity (dr >20:1) via MgCl(2)-accelerated addition of benzylzinc reagents (Knochel type organozinc reagents) to (R)-phenylglycinol methyl ether based imines of trifluoropyruvate. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	氟化学 ; 金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetlet.2011.07.006
语种	英语
WOS记录号	WOS:000294145600022
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28219]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Yang J,Min QQ,HE YI,et al. Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate[J]. Tetrahedron Lett.,2011,52(36):4675-4677.
APA	杨洁,闵巧桥,HE YI,&张新刚.(2011).Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate.Tetrahedron Lett.,52(36),4675-4677.
MLA	杨洁,et al."Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate".Tetrahedron Lett. 52.36(2011):4675-4677.