Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate | |
Yang J(杨洁) ; Min QQ(闵巧桥) ; HE YI ; Zhang XG(张新刚) | |
刊名 | Tetrahedron Lett.
![]() |
2011 | |
卷号 | 52期号:36页码:4675-4677 |
ISSN号 | 0040-4039 |
其他题名 | 通过苄基锌试剂对手性三氟丙酮酸酯亚胺高立体选择性加成合成具有季碳手心的a-氨基酸 |
通讯作者 | 张新刚 |
英文摘要 | An effective and facile method for highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids was developed in good yields with high diastereoselectivity (dr >20:1) via MgCl(2)-accelerated addition of benzylzinc reagents (Knochel type organozinc reagents) to (R)-phenylglycinol methyl ether based imines of trifluoropyruvate. (C) 2011 Elsevier Ltd. All rights reserved. |
学科主题 | 氟化学 ; 金属有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1016/j.tetlet.2011.07.006 |
语种 | 英语 |
WOS记录号 | WOS:000294145600022 |
公开日期 | 2013-08-23 |
内容类型 | 期刊论文 |
源URL | [http://202.127.28.38/handle/331003/28219] ![]() |
专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
推荐引用方式 GB/T 7714 | Yang J,Min QQ,HE YI,et al. Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate[J]. Tetrahedron Lett.,2011,52(36):4675-4677. |
APA | 杨洁,闵巧桥,HE YI,&张新刚.(2011).Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate.Tetrahedron Lett.,52(36),4675-4677. |
MLA | 杨洁,et al."Highly diastereoselective synthesis of quaternary alpha-trifluoromethyl alpha-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate".Tetrahedron Lett. 52.36(2011):4675-4677. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论