Enantioselective Synthesis of (-)-Stemoamide

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	Enantioselective Synthesis of (-)-Stemoamide
	Mi XW(米贤伟) ; Wang Y(王燕) ; Zhu LL(朱莉莉) ; Wang RX(王任小) ; Hong R(洪然)
刊名	Synthesis
	2012
卷号	44 期号:22 页码:3432-3440
ISSN号	0039-7881
其他题名	百部酰胺的对映选择性合成
通讯作者	洪然
英文摘要	An enantioselective synthesis of (-)-stemoamide is presented. Noyori's ruthenium complex catalyzed asymmetric transfer hydrogenation of an alkynone delivered the (S)-C8 stereogenic center in 97.7% ee. An iron(III) chloride promoted and bioinspired N-iminium ion cyclization afforded a 3: 1 ratio of two diastereomers in favor of the cis-isomer. The diastereomeric ratio was enriched to 50: 1 by a silver-catalyzed cycloisomerization. The subsequent dynamic ruthenium-catalyzed CO-insertion reaction secured an enantioselective total synthesis of (-)-stemoamide in 18% overall yield with high optical purity.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1055/s-0032-1317499
语种	英语
WOS记录号	WOS:000312001900003
公开日期	2013-08-29
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28647]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Mi XW,Wang Y,Zhu LL,et al. Enantioselective Synthesis of (-)-Stemoamide[J]. Synthesis,2012,44(22):3432-3440.
APA	米贤伟,王燕,朱莉莉,王任小,&洪然.(2012).Enantioselective Synthesis of (-)-Stemoamide.Synthesis,44(22),3432-3440.
MLA	米贤伟,et al."Enantioselective Synthesis of (-)-Stemoamide".Synthesis 44.22(2012):3432-3440.