Development of a Nonenzymatic Kinetic Resolution of alpha-Allenic Alcohols

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	Development of a Nonenzymatic Kinetic Resolution of alpha-Allenic Alcohols
	Wang Y(王燕) ; Rob Hoen ; Hong R(洪然)
刊名	Synlett
	2012
期号	19 页码:2729-2734
ISSN号	0936-5214
其他题名	发展非酶催化的alpha-联烯醇的环化异构化动力学拆分
通讯作者	洪然
英文摘要	This personal viewpoint lays out the development of a silver-catalyzed kinetic resolution of alpha-allenic alcohols inspired by the biomimetic synthesis of natural products. The corresponding selectivity factor (s) indicates that this resolution protocol can deliver chiral allenic alcohols and 2,5-dihydrofurans in high enantioselectivity with synthetically applicable isolated yields. The broad substrate scope makes it an attractive approach for building synthetically useful chiral building blocks. From the recent progress in allene chemistry, silver was considered as an anion metathesis reagent to prepare highly efficient Au catalysts. Our discovery of the unique reactivity of a chiral silver phosphate should stimulate more interesting discoveries in this field.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1055/s-0032-1317566
语种	英语
WOS记录号	WOS:000311492100002
公开日期	2013-08-29
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28645]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Wang Y,Rob Hoen,Hong R. Development of a Nonenzymatic Kinetic Resolution of alpha-Allenic Alcohols[J]. Synlett,2012(19):2729-2734.
APA	王燕,Rob Hoen,&洪然.(2012).Development of a Nonenzymatic Kinetic Resolution of alpha-Allenic Alcohols.Synlett(19),2729-2734.
MLA	王燕,et al."Development of a Nonenzymatic Kinetic Resolution of alpha-Allenic Alcohols".Synlett .19(2012):2729-2734.