synthesisofnadanalogstodevelopbioorthogonalredoxsystem

	synthesisofnadanalogstodevelopbioorthogonalredoxsystem
	Ji Debin; Wang Lei; Liu Wujun; Hou Shuhua; Zhao Zongbao K
刊名	sciencechinachemistry
	2013-01-01
卷号	56 期号:3 页码:296
ISSN号	1674-7291
英文摘要	Three new nicotinamide adenine dinucleotide(NAD) analogs were synthesized, and their characteristics as cofactors for Escherichia coli malic enzyme(ME) and its double mutant ME L310R/Q401C were analyzed.Each pair of the NAD analog and the double mutant showed good orthogonality to the natural pair of NAD and ME in terms of catalyzing oxidative decarboxylation of L-malic acid.Results indicated that molecular interactions between redox enzyme and cofactor could be further explored to generate new bioorthogonal redox systems.
语种	英语
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/178419]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	中国科学院大连化学物理研究所
推荐引用方式 GB/T 7714	Ji Debin,Wang Lei,Liu Wujun,et al. synthesisofnadanalogstodevelopbioorthogonalredoxsystem[J]. sciencechinachemistry,2013,56(3):296.
APA	Ji Debin,Wang Lei,Liu Wujun,Hou Shuhua,&Zhao Zongbao K.(2013).synthesisofnadanalogstodevelopbioorthogonalredoxsystem.sciencechinachemistry,56(3),296.
MLA	Ji Debin,et al."synthesisofnadanalogstodevelopbioorthogonalredoxsystem".sciencechinachemistry 56.3(2013):296.