Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds

doi:10.1016/j.talanta.2019.03.103

	Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds
	Chen, Xuan 2,3; Hua, Lei 2; Jiang, Jichun 2; Hu, Fan 1; Wan, Ningbo 2,3; Li, Haiyang 2
刊名	TALANTA
	2019-08-15
卷号	201 页码:33-39
关键词	High-pressure photoionization time-of-flight mass-spectrometry Multi-capillary column Rapid analysis Matrix effect Isomer separation Flavor compounds High-pressure photoionization time-of-flight mass-spectrometry Multi-capillary column Rapid analysis Matrix effect Isomer separation Flavor compounds
ISSN号	0039-9140
DOI	10.1016/j.talanta.2019.03.103
通讯作者	Hua, Lei(lhua@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要	High-pressure photoionization time-of-flight mass spectrometry (HPPI-TOFMS) is a versatile and highly sensitive analytical technique for online and real-time analysis of trace volatile organic compounds in complex mixtures. However, discrimination of isomers is usually a great challenge for the soft ionization method, and matrix effect is also inevitable under high pressure in the HPPI source. In this work, we describe a first attempt to develop a two-dimensional (2D) hyphenated instrument by coupling of a multi-capillary column (MCC) with a HPPI-TOFMS to overcome these problems. The capability of the MCC-HPPI-TOFMS for discrimination of isomeric compounds and elimination of the matrix effect was demonstrated by analyzing flavor mixtures. With the merits of fast separation, soft ionization and high detection sensitivity, satisfactory effects in the 2D analysis were achieved, despite the relatively low chromatographic resolution of MCC. As a result, three isomers, eucalyptol, L-menthone and linalool, in a flavor mixture were successfully categorized within 90 s, and the matrix effect caused by solvent ethanol was significantly eliminated as well. The limits of detection (LODs) down to sub-ppbv level were achieved for the investigated five flavor compounds without any enrichment process, and an excellent repeatability was obtained with the relative standard deviations (RSDs) of signal intensities <= 5%. The MCC-HPPI-TOFMS system was preliminarily applied for rapid and online analysis of flavor compounds in(t)he exhaled gas of a volunteer after mouth rinsing with a gargle product. The rapid changes of the three flavor compounds, as well as the steady endogenous metabolite acetone, in the exhaled gas were successfully determined with a time-resolution of only 1.5 min.
资助项目	National Natural Science Foundation of China[21675155] ; National Natural Science Foundation of China[21605142]
WOS关键词	SINGLE-PHOTON IONIZATION ; SOLID-PHASE MICROEXTRACTION ; ION MOBILITY SPECTROMETRY ; VACUUM-ULTRAVIOLET LAMP ; HUMAN URINE ; TOF-MS ; GAS ; QUANTIFICATION ; GC ; METABOLITES
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000471084300005
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/175790]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Hua, Lei; Li, Haiyang
作者单位	1.Henan Prov Med Instrument Testing Inst, 79 Xiongerhe Rd, Zhengzhou 450018, Henan, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xuan,Hua, Lei,Jiang, Jichun,et al. Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds[J]. TALANTA,2019,201:33-39.
APA	Chen, Xuan,Hua, Lei,Jiang, Jichun,Hu, Fan,Wan, Ningbo,&Li, Haiyang.(2019).Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds.TALANTA,201,33-39.
MLA	Chen, Xuan,et al."Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds".TALANTA 201(2019):33-39.