Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts
	Nian, Yin1 ; Zhu, Hui 2; Tang, Wen-Ru 2; Luo, Yin 2; Du, Jiang 3; Qiu, Ming-Hua1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013-05-01
卷号	76 期号:5 页码:896-902
关键词	SIMPLEX WORMSK 9 19-CYCLOLANOSTANE DERIVATIVES CYCLOARTANE TRITERPENOIDS CONSTITUENTS GLYCOSIDES RACEMOSA DAHURICA ROOTS
ISSN号	0163-3864
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem Plant Resources West Chin, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn
英文摘要	Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), and cimilactone C (9), and 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The new structures were established using a combination of MS, NMR, and single-crystal X-ray diffraction techniques. WT MEFs (wildtype mouse embryonic fibroblasts) and tumorigenic cell lines p53(-/-)+H-RasV12 and ps3(-/-)+p53(N236S)+H-RasV12 were used for evaluating active structures, targeting p53(N236S) (corresponding to p53(N239S) in humans) mutation. Compound 5 showed nonselective activities against these cell lines, with IC50 values of 5.8, 8.6, and 6.0 mu M, respectively. Compound 4 exhibited greater selectivity against the p53(-/-)+p53(N236S)+H-RasV12 cells (IC50 5.5 mu M) than against the WT MEFs cells (IC50 14.3 mu M).
学科主题	Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	SIMPLEX WORMSK ; 9,19-CYCLOLANOSTANE DERIVATIVES ; CYCLOARTANE TRITERPENOIDS ; CONSTITUENTS ; GLYCOSIDES ; RACEMOSA ; DAHURICA ; ROOTS
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [U1132604]; Knowledge Innovation Program of the CAS [KZCX2-XB2-15-03, KSCX2-EW-R-15]; Top Talents Program of Yunnan Province [2009C1120]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]
语种	英语
WOS记录号	WOS:000319650600012
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16547]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem Plant Resources West Chin, Kunming 650201, Peoples R China 2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China 3.Dengzhanhua Pharmaceut Co Ltd, Res Inst Yunnan Biovalley, Kunming 650224, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Zhu, Hui,Tang, Wen-Ru,et al. Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(5):896-902.
APA	Nian, Yin,Zhu, Hui,Tang, Wen-Ru,Luo, Yin,Du, Jiang,&Qiu, Ming-Hua.(2013).Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts.JOURNAL OF NATURAL PRODUCTS,76(5),896-902.
MLA	Nian, Yin,et al."Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts".JOURNAL OF NATURAL PRODUCTS 76.5(2013):896-902.