Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd

	Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd
	Hua, Lei ; Li, Ya ; Wang, Fei ; Lu, Dan-feng ; Gao, Kun
刊名	FITOTERAPIA
	2012
卷号	83 期号:6 页码:1036-1041
关键词	Vernonia anthelmintica Willd Vernoanthelsterone A Estrogen biosynthesis Antibacterial activities
ISSN号	0367-326X
通讯作者	Gao, K (reprint author), Zhejiang Univ, Ningbo Inst Technol, Sch Biotechnol & Chem Engn, Ningbo 315100, Zhejiang, Peoples R China.
产权排序	3
英文摘要	A new steroid, vernoanthelsterone A (1), and five known steroids were isolated from the aerial parts of Vernonia anthelmintica Willd. Compound 1 possesses a Delta(8(14))-15-one moiety. To our best knowledge, few steroids with this moiety have been reported before. Compounds 1-6 were tested for their antibacterial activities and their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells). Compound 2 showed the ability to promote estrogen biosynthesis with EC50 of 56.95 mu g/mL and also exhibited the antibacterial activities against Bacillus cereus, Staphyloccocus aureus, Bacillus subtilis and Escherichia coli with MICs ranging from 3.15 to 15.5 mu g/mL. The structures of 1-6 were determined on the basis of IR, MS, 1D and 2D NMR. (C) 2012 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
收录类别	SCI
资助信息	National Natural Science Foundation of China [20972062, 21172196]
语种	英语
WOS记录号	WOS:000308116600009
公开日期	2013-07-03
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/23883]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Hua, Lei,Li, Ya,Wang, Fei,et al. Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd[J]. FITOTERAPIA,2012,83(6):1036-1041.
APA	Hua, Lei,Li, Ya,Wang, Fei,Lu, Dan-feng,&Gao, Kun.(2012).Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd.FITOTERAPIA,83(6),1036-1041.
MLA	Hua, Lei,et al."Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd".FITOTERAPIA 83.6(2012):1036-1041.