In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers

	In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers
	Li D ; Ding JX ; Tang ZH ; Sun H ; Zhuang XL ; Xu JZ ; Chen XS
刊名	international journal of nanomedicine
	2012
卷号	7 页码:2687-2697
关键词	POLYMERIC MICELLES DRUG CARRIER NANOPARTICLES DELIVERY PH
ISSN号	1178-2013
通讯作者	tang zh
中文摘要	four monomethoxy poly(ethylene glycol)-poly(l-lactide-co-glycolide)(2) (mpeg-p(la-co-ga)(2)) copolymers were synthesized by ring-opening polymerization of l-lactide and glycolide with double hydroxyl functionalized mpeg (mpeg-(oh)(2)) as macroinitiator and stannous octoate as catalyst. the copolymers self-assembled into nanoscale micellar/vesicular -aggregations in phosphate buffer at ph 7.4. doxorubicin (dox), an anthracycline anticancer drug, was loaded into the micellar/vesicular nanoparticles, yielding micellar/vesicular nanomedicines. the in vitro release behaviors could be adjusted by content of hydrophobic polyester and ph of the release medium. in vitro cell experiments showed that the intracellular dox release could be adjusted by content of p(la-co-ga), and the nanomedicines displayed effective proliferation inhibition against henrietta lacks's cells with different culture times. hemolysis tests indicated that the copolymers were hemocompatible, and the presence of copolymers could reduce the hemolysis ratio of dox significantly. these results suggested that the novel anticancer nanomedicines based on dox and amphiphilic y-shaped copolymers were attractive candidates as tumor tissular and intracellular targeting drug delivery systems in vivo, with enhanced stability during circulation and accelerated drug release at the target sites.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000304807000001
公开日期	2013-06-30
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48539]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li D,Ding JX,Tang ZH,et al. In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers[J]. international journal of nanomedicine,2012,7:2687-2697.
APA	Li D.,Ding JX.,Tang ZH.,Sun H.,Zhuang XL.,...&Chen XS.(2012).In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers.international journal of nanomedicine,7,2687-2697.
MLA	Li D,et al."In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers".international journal of nanomedicine 7(2012):2687-2697.