Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker

	Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker
	Hu XL ; Wang R ; Yue J ; Liu S ; Xie ZG ; Jing XB
刊名	journal of materials chemistry
	2012
卷号	22 期号:26 页码:13303-13310
关键词	AMPHIPHILIC BLOCK-COPOLYMERS HPMA COPOLYMERS DRUG-DELIVERY DESIGN TUMOR FUNCTIONALIZATION MICELLES
ISSN号	0959-9428
通讯作者	jing xb
中文摘要	multifunctional micelles were successfully prepared by co-assembling a doxorubicin-conjugated copolymer (mpeg-b-p(la-co-me/dox), for antitumor properties) and a rhodamine b-conjugated copolymer (mpeg-b-p(la-co-me/rhb), for imaging) with a folic acid (fa)-conjugated copolymer (fa-peg-b-pla, for targeting), respectively. dls showed that the sizes of these micelles were in the range of 150-300 nm. fluorescent imaging analysis based on the rhb signals of the isolated visceral organs showed that the micelles with or without fa moieties were mainly accumulated in the liver and in the tumor from 2 h post drug administration, maximized at ca. 6 h, and decayed afterwards. more fa-carrying micelles were accumulated in the tumor for a longer time compared to the micelles without fa moieties. dox-containing micelles were used for tumor inhibition experiments in vivo and the results showed that the micelles with fa moieties exhibited better antitumor efficacy than those without fa and free dox.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000305242300047
公开日期	2013-06-30
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48532]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Hu XL,Wang R,Yue J,et al. Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker[J]. journal of materials chemistry,2012,22(26):13303-13310.
APA	Hu XL,Wang R,Yue J,Liu S,Xie ZG,&Jing XB.(2012).Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker.journal of materials chemistry,22(26),13303-13310.
MLA	Hu XL,et al."Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker".journal of materials chemistry 22.26(2012):13303-13310.