A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior

	A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior
	Li B ; Chen G ; Meng FB ; Li TH ; Yue J ; Jing XB ; Huang YB
刊名	polymer chemistry
	2012
卷号	3 期号:9 页码:2421-2429
关键词	ARTIFICIAL OXYGEN CARRIERS DRUG-DELIVERY BLOCK-COPOLYMERS GRAFT-COPOLYMERS HEMOGLOBIN-VESICLES NANOPARTICLES LIPOSOMES GLYCOL)S MICELLES FUNCTIONALIZATION
ISSN号	1759-9954
通讯作者	meng fb
中文摘要	new amphiphilic graft copolymers with hydrophilic poly(ethylene oxide-co-allyl glycidyl ether) (peag) as the backbone and hydrophobic poly(epsilon-caprolactone) (pcl) as the side chains (peag-g-pcl) were designed and synthesized. for this purpose, the combined techniques of anionic copolymerization, radical mediated thiol-ene reaction and ring-opening polymerization were employed. the properties of the graft copolymer were characterized by h-1 nmr, c-13 nmr, gpc and maldi-tof-ms. the self-assembly of the copolymers in aqueous solution was examined by fluorescence spectroscopy, dls and tem. the results showed that with a relatively low critical aggregation concentration (cac), the graft copolymers could form different morphologies including vesicles (polymersomes). the formed polymersomes had the capacity to encapsulate protein molecules (like hemoglobin, hb) through a modified lyophilization-rehydration method as analyzed via tem and sds-page. furthermore the gas-binding capacity of the encapsulated hb was assayed via uv-vis spectroscopy. the characteristic absorption peak of the encapsulated hb in different gas-binding states (co, o-2, n-2) showed no significant change by comparison with that of free hb. these hb encapsulated peag-g-pcl polymersomes could have the potential to be applied as an artificial oxygen carrier for transfusion.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000306967600013
公开日期	2013-06-30
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48486]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li B,Chen G,Meng FB,et al. A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior[J]. polymer chemistry,2012,3(9):2421-2429.
APA	Li B.,Chen G.,Meng FB.,Li TH.,Yue J.,...&Huang YB.(2012).A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior.polymer chemistry,3(9),2421-2429.
MLA	Li B,et al."A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior".polymer chemistry 3.9(2012):2421-2429.