Two efficient four-step routes to marine toxin tanikolide

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	Two efficient four-step routes to marine toxin tanikolide
	Chen QS(陈庆寿) ; Deng HB(邓海兵) ; Zhao JR(赵景瑞) ; Lu Y(路勇) ; He MY(何鸣元) ; Zhai HB(翟宏斌)
刊名	Tetrahedron
	2005
卷号	61 期号:35 页码:8390-8393
ISSN号	0040-4020
其他题名	四步法高效合成海洋毒素 tanikolide 的两条路线
通讯作者	翟宏斌
英文摘要	We have presented two facile four-step syntheses of (+/-)-tanikolide from ethyl 2-oxocyclopentanecarboxylate. The overall chemical yields of the two sequences reached as high as 76 and 85%, respectively. The first strategy involved alkylation. Baeyer-Villiger reaction. saponification, and reduction/lactonization. The second approach for synthesizing tanikolide took advantage of the same intermediate, the alkylated ketoester 2, which was converted to the target molecule in such three steps is deethoxycarbonylation, hydroxymethylation, and Baeyer-Villiger reaction. Our strategies are advantageous because of their high yields and suitability for the preparation of I in multigram or larger quantities.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tet.2005.06.098
语种	英语
WOS记录号	WOS:000231211800010
公开日期	2013-06-19
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/25581]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Chen QS,Deng HB,Zhao JR,et al. Two efficient four-step routes to marine toxin tanikolide[J]. Tetrahedron,2005,61(35):8390-8393.
APA	陈庆寿,邓海兵,赵景瑞,路勇,何鸣元,&翟宏斌.(2005).Two efficient four-step routes to marine toxin tanikolide.Tetrahedron,61(35),8390-8393.
MLA	陈庆寿,et al."Two efficient four-step routes to marine toxin tanikolide".Tetrahedron 61.35(2005):8390-8393.