Since pactamycin has important application values in biochemistry and medicine, its synthesis has received extensive attention of chemists in recent years. The core structure of pactamycin is cyclopentane, and its C-3 has the structure of meta-amino acetophenone. This structure can be generated from nucleophilic addition reactions between 3- acetyl benzyne and aminocyclopentitol of pactamycin. The classic coupling between amines and halogenated armotic compounds were catalyzed by transition metals. However, there are many drawbacks for the reaction, such as, the harsh reaction conditions, poor compatibility of the functional groups and narrow scope of the substrates. Moreover, the complex structure of aminocyclopentit- ol leads that it is rather difficult to get meta-acetophenone at C-3 of pactamycin through the reaction between aminocyclopentitol and halogenated armotic compounds catalyzed by transitional metals Therefore, the main work of this paper is: (1)To synthesize the precursor 2-acetyl-6-((trimethylsilyl)phenyl trifluorometha- nesulfonate which could produce 3-acetyl benzyne under mild conditions. (2)To modify 3 - acetyl, and through controlling the electronic effect and steric effect to realize selective meta- nucleophilic addition of amine to 3-acetyl benzyne. (3)To explore the nucleophilic addition reaction between 3-acetyl benzyne and amine in which 3-acetyl benzyne was generated from 2- acetyl-6-(trimethyl)-phenyl thifluoromethanesulfonate in the presence of F- under mild condition .. 2-Acetyl-6-(trimethylsilyl)phenyl trifluoromethanesulfonate was synthesized fro- m 2-(trimethylsilyl)phenol .And it’s functional group was modified. The nucleophilic addition reaction between 2-Acetyl-6-(trimethylsilyl)phenyl trifluoromethanesulfonate and amines got moderate yield. The research will have potential application values for the structure building of memo- acetophenone at C-3 of natural pactamycin