Proton production, regulation and pathophysiological roles in the mammalian brain

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	Proton production, regulation and pathophysiological roles in the mammalian brain
	Zeng, WZ ; Xu, TL
刊名	NEUROSCIENCE BULLETIN
	2012
卷号	28 期号:1 页码:1-13
关键词	SENSING ION CHANNELS GABA(A) RECEPTOR TRAFFICKING GATED CALCIUM-CHANNELS CENTRAL-NERVOUS-SYSTEM LONG-TERM-MEMORY H EXCHANGER NHE1 INTRACELLULAR PH MOLECULAR-BASIS CELL-MIGRATION SNAIL NEURONS
ISSN号	1673-7067
通讯作者	Xu, TL (reprint author), Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Neurosci Div,Dept Biochem & Mol Cell Biol, Shanghai 200025, Peoples R China.,xu-happiness@shsmu.edu.cn
英文摘要	The recent demonstration of proton signaling in C. elegans muscle contraction suggests a novel mechanism for proton-based intercellular communication and has stimulated enthusiasm for exploring proton signaling in higher organisms. Emerging evidence indicates that protons are produced and regulated in localized space and time. Furthermore, identification of proton regulators and sensors in the brain leads to the speculation that proton production and regulation may be of major importance for both physiological and pathological functions ranging from nociception to learning and memory. Extracellular protons may play a role in signal transmission by not only acting on adjacent cells but also affecting the cell from which they were released. In this review, we summarize the upstream and downstream pathways of proton production and regulation in the mammalian brain, with special emphasis on the proton extruders and sensors that are critical in the homeostatic regulation of pH, and discuss their potential roles in proton signaling under normal and pathophysiological conditions.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Basic Research Development Program of China [2011CBA00408]; National Natural Science Foundation of China [30830035]; Shanghai Municipal People's Government [09XD1404900]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2496]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zeng, WZ,Xu, TL. Proton production, regulation and pathophysiological roles in the mammalian brain[J]. NEUROSCIENCE BULLETIN,2012,28(1):1-13.
APA	Zeng, WZ,&Xu, TL.(2012).Proton production, regulation and pathophysiological roles in the mammalian brain.NEUROSCIENCE BULLETIN,28(1),1-13.
MLA	Zeng, WZ,et al."Proton production, regulation and pathophysiological roles in the mammalian brain".NEUROSCIENCE BULLETIN 28.1(2012):1-13.