Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons

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	Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons
	Zhang, X
刊名	NEUROSCIENCE BULLETIN
	2012
卷号	28 期号:2 页码:121-130
关键词	DORSAL-ROOT GANGLIA PROTEIN-COUPLED RECEPTORS DENSE-CORE VESICLES RAT SPINAL-CORD MORPHINE-TOLERANCE MESSENGER-RNAS KNOCKOUT MICE AUTORADIOGRAPHIC LOCALIZATION PHYSICAL-DEPENDENCE PERIPHERAL AXOTOMY
ISSN号	1673-7067
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	mu-opioid receptor (MOR) agonists such as morphine are powerful analgesics used for pain therapy. However, the use of these drugs is limited by their side-effects, which include antinociceptive tolerance and dependence. Earlier studies reported that MOR analgesic tolerance is reduced by blockade of delta-opioid receptors (DORs) that interact with MORs. Recent studies show that the MOR/DOR interaction in nociceptive afferent neurons in the dorsal root ganglion may contribute to morphine analgesic tolerance. Further analysis of the mechanisms for regulating the trafficking of receptors, ion channels and signaling molecules in nociceptive afferent neurons would help to understand the nociceptive mechanisms and improve pain therapy.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China [31130066]; National Basic Research Development Program of China [2009CB522005, 2011CBA00400]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2486]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, X. Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons[J]. NEUROSCIENCE BULLETIN,2012,28(2):121-130.
APA	Zhang, X.(2012).Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons.NEUROSCIENCE BULLETIN,28(2),121-130.
MLA	Zhang, X."Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons".NEUROSCIENCE BULLETIN 28.2(2012):121-130.