Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch

	Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch
	Kang XJ ; Cheng ZY ; Yang DM ; Ma PA ; Shang MM ; Peng C ; Dai YL ; Lin J
刊名	advanced functional materials
	2012
卷号	22 期号:7 页码:1470-1481
关键词	SUSTAINED-RELEASE PROPERTY POLY N-ISOPROPYLACRYLAMIDE CORE-SHELL STRUCTURE SENSITIVE HYDROGELS UP-CONVERSION BIOMEDICAL APPLICATIONS HYBRID COMPOSITES DELIVERY SYSTEMS NANOPARTICLES NANOCRYSTALS
ISSN号	1616-301x
通讯作者	kang xj
中文摘要	a novel approach for the fabrication of multifunctional microspheres integrating several advantages of mesoporous, luminescence, and temperature responses into one single entity is reported. first, the hollow mesoporous silica capsules are fabricated via a sacrificial template route. then, gd2o3:eu3+ luminescent nanoparticles are incorporated into the internal cavities to form rattle-type mesoporous silica nanocapsules by an incipient-wetness impregnation method. finally, the rattle-type capsules serve as a nanoreactor for successfully filling temperature-responsive hydrogel via photoinduced polymerization to form the multifunctional composite microspheres. the organicinorganic hybrid microspheres show a red emission under uv irradiation due to the luminescent gd2o3:eu3+ core. the in vitro cytotoxicity tests show that the samples have good biocompatibility, which indicates that the nanocomposite could be a promising candidate for drug delivery. in addition, flow cytometry and confocal laser scanning microscopy (clsm) confirm that the sample can be effectively taken up by skov3 cells. for in vitro magnetic resonance imaging (mri), the sample shows the promising spin-lattice relaxation time (t1) weighted effect and could potentially apply as a t1-positive contrast agent. this composite drug delivery system (dds) provides a positive temperature controlled on-offdrug release pattern and the drug, indomethacin (imc), is released fast at 45 degrees c (on phase) and completely shut off at 20 degrees c (off phase). meanwhile gd2o3:eu3+ plays an important role as the luminescent tag for tracking the drug loading and release process by the reversible luminescence quenching and recovery phenomenon. these results indicate that the obtained multifunctional composite has the potential to be used as a smart dds for biomedical applications.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000302346400016
公开日期	2013-05-22
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48230]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kang XJ,Cheng ZY,Yang DM,et al. Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch[J]. advanced functional materials,2012,22(7):1470-1481.
APA	Kang XJ.,Cheng ZY.,Yang DM.,Ma PA.,Shang MM.,...&Lin J.(2012).Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch.advanced functional materials,22(7),1470-1481.
MLA	Kang XJ,et al."Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle-Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch".advanced functional materials 22.7(2012):1470-1481.