INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES

	INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES
	Dong D ; Chen F ; Fu Y ; Wang R ; Zheng YH ; Jing XB
刊名	acta polymerica sinica
	2012
期号	8 页码:915-922
关键词	HYPERSENSITIVITY REACTIONS PACLITAXEL CISPLATIN AGENTS
ISSN号	1000-3304
通讯作者	dong d
中文摘要	two amphiphilic biodegradable block copolymers, poly(ethylene glycol)-b-poly(lactide-co-carbonate), were prepared and then conjugated with paclitaxel (ptx) and folic acid (fa), respectively, to form polymer-ptx conjugate and polymer-fa conjugate. these two conjugates were co-assembled into composite nanomicelles with an average diameter of ca. 50 nm, a ptx content of 27 wt% and a fa content of 1.4 wt%. human ovarian cancer skov3 cells were cultured. mtt assay and flow cytometry analysis showed that taxol,m(ptx) and fa-m(ptx) could inhibit the growth of skov3 cells at a ptx concentration of 10 mu g/ml,m(ptx) and fa-m (ptx) were more efficient than taxol. xenograft subcutaneous skov3 cancer models were constructed in balb/c mice. inhibition of the tumor growth by taxol, m (ptx) and fa:ni(ptx) was examined. at a dosage of 20 mg/kg, the tumor volume measurement, the tumor weight measurement on the 9th day and the survival curve all showed that taxol,m(ptx) and fa-m(ptx) could inhibit the growth of the skov3 cancers, in the order of taxol
收录类别	SCI收录期刊论文
语种	中文
WOS记录号	WOS:000309198100019
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47996]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Dong D,Chen F,Fu Y,et al. INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES[J]. acta polymerica sinica,2012(8):915-922.
APA	Dong D,Chen F,Fu Y,Wang R,Zheng YH,&Jing XB.(2012).INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES.acta polymerica sinica(8),915-922.
MLA	Dong D,et al."INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES".acta polymerica sinica .8(2012):915-922.