Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery

	Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery
	Kuang HH ; Wu SH ; Xie ZG ; Meng FB ; Jing XB ; Huang YB
刊名	biomacromolecules
	2012
卷号	13 期号:9 页码:3004-3012
关键词	MOLECULAR RECOGNITION HYDROGEN-BONDS DIBLOCK COPOLYMERS BLOCK-COPOLYMERS SDS MICELLES POLYMER DOXORUBICIN VESICLES SOLVENTS BEHAVIOR
ISSN号	1525-7797
通讯作者	meng fb
中文摘要	biodegradable nucleobase-grafted amphiphilic copolymer, the methoxyl poly (ethylene glycol)-b-poly (l-lactide-omega-2-methyl-2(3-(2,3-dihydroxylpropylthio) propyloxycarbonyl)-propylene carbonate/1-carboxymethylthymine) (mpeg-b- p(la-co-mpt)), was synthesized. h-1 nmr titration and ft-ir spectroscopy indicated that the hydrogen-bonding could be formed between mpeg-b-p(la-co-mpt) and 9-hexadecyladenine (a-c16). the hydrophobic microenvironment of the amphiphilic copolymer can protect the complementary multiple hydrogen bonds between mpeg-b-p(la-co-mpt) and a-c16 from water effectively. the addition of a-c16 not only lowered the critical aggregation concentration (cac) of mpeg-b-p(la-co-mpt)/a-c16 nanoparticles (nps) in aqueous solution but also induced different morphologies, which can be observed by transmission electron microscopy (tem). meanwhile, dynamic light scattering (dls) and turbidometry was utilized to evaluate the effect of temperature and ph change on the stability of mpeg-b-p(la-co-mpt)/a-c16 nps. cytotoxicity evaluation showed good biocompatibility of the mpeg-b-p(la-co-mpt)/a-c16 nps. the in vitro drug release profile showed that with the increase of a-c16 content, the doxorubiucin (dox) release at ph 7.4 decreased, while the faster release rate was observed with the addition of a-c16 with a ph of 5.0. importantly, dox-loaded nps exerted comparable cytotoxicity against mda-mb-231 cells. this work provided a new method to stabilize np structure using hydrogen-bonds and would have the potential to be applied in controlled drug delivery.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000308508500044
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47971]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kuang HH,Wu SH,Xie ZG,et al. Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery[J]. biomacromolecules,2012,13(9):3004-3012.
APA	Kuang HH,Wu SH,Xie ZG,Meng FB,Jing XB,&Huang YB.(2012).Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery.biomacromolecules,13(9),3004-3012.
MLA	Kuang HH,et al."Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery".biomacromolecules 13.9(2012):3004-3012.