Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent

	Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent
	Liu Z ; Li ZH ; Liu JH ; Gu S ; Yuan QH ; Ren JS ; Qu XG
刊名	biomaterials
	2012
卷号	33 期号:28 页码:6748-6757
关键词	BISMUTH SULFIDE NANOPARTICLES COMPUTED-TOMOGRAPHY GOLD NANOPARTICLES HOLLOW SPHERES NANOPROBES THERAPY CANCER MEDIA BIODISTRIBUTION NANOPHOSPHORS
ISSN号	0142-9612
通讯作者	ren js
中文摘要	nanoparticulate imaging agents offer excellent diagnostic and therapeutic capabilities due to their intense and stable output, strong target binding via multiple ligands, as well as tunable biodistribution profiles. in the present work, we designed and synthesized pegylated yb2o3:er nanoparticles with high yb content in single particle (denoted as peg-ucnps) suitable for both x-ray ct imaging and up-conversion imaging. these peg-ucnps were facile to construct, possessed excellent stability against in vivo environment, and held long blood circulation time. cell-cytotoxicity assay, hemolyticity, and post-injection histology analysis further demonstrated the excellent biocompatibility, indicating the feasibilities of peg-ucnps for in vivo applications. compared with routinely used iobitridol in clinic, well-prepared peg-ucnps provided much significantly enhanced contrast at a clinical 120 kvp voltage. by doping 5% er3+ into the nanoparticles, peg-ucnps presented a long-term stable and nearly single-band red up-conversion emission upon continuous irradiation with an assistant of a 980 laser. in addition, pharmacokinetics, biodistribution, as well as clearance of nanoparticles were studied after intravenous injection in a mouse model, reflecting their overall safety. peg-ucnps composed of intrinsic up-conversion luminescence property, higher x-ray absorption over lobitridol, as well as excellent biocompatibility represented a nanoplatform for biomedicine applications. (c) 2012 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000308270000017
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47932]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu Z,Li ZH,Liu JH,et al. Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent[J]. biomaterials,2012,33(28):6748-6757.
APA	Liu Z.,Li ZH.,Liu JH.,Gu S.,Yuan QH.,...&Qu XG.(2012).Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent.biomaterials,33(28),6748-6757.
MLA	Liu Z,et al."Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent".biomaterials 33.28(2012):6748-6757.