pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium
	Hua SB(华水波)1,2; Yang HX(杨会霞)1,2; Li Q(李琼)3; Zhang JP(张俊平)1 ; Wang AQ(王爱勤)1 ; Wang AQ(王爱勤)
刊名	Drug Development and Industrial Pharmacy
	2012
卷号	38 期号:6 页码:728-734
关键词	Bead alginate hydrotalcite drug release diclofenac sodium
ISSN号	0363-9045
通讯作者	王爱勤
英文摘要	Objective: The aim of this study was to prepare pH-sensitive sodium alginate/calcined hydrotalcite (SA/CHT) hybrid bead with improved the burst release effect of the drug. Materials and methods: A series of pH-sensitive SA/CHT hybrid beads were prepared by using Ca²⁺ cross-linking in the presence of diclofenac sodium (DS) and SA. The structure and drug loading of the beads were characterized by Fourier transform infrared spectroscopy and X-ray diffraction. The swelling and the drug release of the fabricated beads were investigated by the pH of test medium and CHT content. Result: The formed positively charged hydrotalcite layers were adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic cross-linkers in the three-dimensional network. Compared to pure SA beads, the incorporation of CHT enhanced the drug encapsulation efficiency, improved the swelling behaviors and slowed the drug release from the hybrid beads. Discussion and conclusions: The electrostatic interaction between hydrotalcite and SA has restricted the movability of the SA polymer chains, and then slowed down swelling and dissolution rates in aqueous solutions. The results provided a simple method to moderate drug release and matrix degradation of the SA beads.
学科主题	环境材料与生态化学
收录类别	SCI
资助信息	the National Natural Science Foundation of China (No. 51003112);the Special Research Fund of Scholarship of Dean of CAS
语种	英语
WOS记录号	WOS:000303327000010
公开日期	2013-03-24
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/2534]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
通讯作者	Wang AQ(王爱勤)
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Hua SB,Yang HX,Li Q,et al. pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium[J]. Drug Development and Industrial Pharmacy,2012,38(6):728-734.
APA	Hua SB,Yang HX,Li Q,Zhang JP,Wang AQ,&王爱勤.(2012).pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium.Drug Development and Industrial Pharmacy,38(6),728-734.
MLA	Hua SB,et al."pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium".Drug Development and Industrial Pharmacy 38.6(2012):728-734.