HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP | |
Zongbin Cui ; Zuoyan Zhu | |
刊名 | FISH PHYSIOLOGY AND BIOCHEMISTRY
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1993 | |
卷号 | 12期号:2页码:161-169 |
关键词 | COMMON CARP CRUCIAN CARP GROWTH HORMONE GROWTH HORMONE GENE TRANSGENIC FISH HORMONAL REPLACEMENT HYPOPHYSECTOMY |
中文摘要 | Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 and F2 transgenics. Following hypophysectomy of the transgenic F2 common carp, non-transgenic common carp and non-transgenic crucian carp, growth was monitored for up to 110 days. In addition, recombinant hGH was injected subcutaenously into a group of the non-transgenic crucian carp. Growth rate analyses indicated that (1) hypophysectomy of non-transgenic common carp and crucian carp results in the cessation of growth, (2) hGH administration can stimulate the growth of hypophysectomized crucian carp and (3) hypophysectomized hGH-transgenic common carp continue to grow in the absence of their own growth hormone, suggesting that the hGH-transgene is being expressed in tissues other than the pituitary. |
学科主题 | Biochemistry & Molecular Biology; Fisheries; Physiology |
收录类别 | SCI |
公开日期 | 2010-10-13 |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/152342/10324] ![]() |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前)_期刊论文 |
推荐引用方式 GB/T 7714 | Zongbin Cui,Zuoyan Zhu. HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,1993,12(2):161-169. |
APA | Zongbin Cui,&Zuoyan Zhu.(1993).HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP.FISH PHYSIOLOGY AND BIOCHEMISTRY,12(2),161-169. |
MLA | Zongbin Cui,et al."HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP".FISH PHYSIOLOGY AND BIOCHEMISTRY 12.2(1993):161-169. |
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