Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy

	Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy
	Xiao HH ; Li WL ; Qi RG ; Yan LS ; Wang R ; Liu S ; Zheng YH ; Xie ZG ; Huang YB ; Jing XB
刊名	journal of controlled release
	2012
卷号	163 期号:3 页码:304-314
关键词	PLATINUM(IV) COMPLEXES ANTICANCER DRUGS DAUNORUBICIN CARDIOTOXICITY ENDOMETRIAL CARCINOMA OVARIAN-CANCER PHASE-III CISPLATIN DOXORUBICIN GLUTATHIONE REDUCTION
ISSN号	0168-3659
通讯作者	jing xb
中文摘要	an oxaliplatin pro-drug (oxa(iv)-cooh) with an axial carboxyl group was synthesized and conjugated to biodegradable polymers with pendant hydroxyl groups to prepare polymer-oxa(iv) conjugates. a hydrophobic anthracycline-based drug, daunorubicin (drb) was conjugated to similar biodegradable polymers with carboxyl groups to synthesize polymer-drb conjugates. the two drug conjugates have the similar polymer backbone and are amphiphilic; thus, they can co-assemble into composite micelles. in the composite micelles, the polymer-oxa(iv) conjugates can release clinically widely used water soluble anticancer drug oxaliplatin (oxa(ii)) upon reduction, while polymer-drb conjugate is thought to release drb via acid hydrolysis in the cancer cells. in this way, combination of the hydrophilic platinum drug oxa(ii) and hydrophobic drug drb can be realized by delivering them in one platform. moreover, the composite micelles showed reduced systematic toxicity and greater synergistic effect than combination of small molecules of the two anticancer drugs both in vitro and in vivo; thus, this polymer based combination therapy can be useful in future clinic application. (c) 2012 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000312266500005
公开日期	2013-03-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47846]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xiao HH,Li WL,Qi RG,et al. Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy[J]. journal of controlled release,2012,163(3):304-314.
APA	Xiao HH.,Li WL.,Qi RG.,Yan LS.,Wang R.,...&Jing XB.(2012).Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy.journal of controlled release,163(3),304-314.
MLA	Xiao HH,et al."Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy".journal of controlled release 163.3(2012):304-314.