Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery

	Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery
	Zhou DF ; Xiao HH ; Meng FB ; Zhou SY ; Guo JS ; Li XY ; Jing XB ; Huang YB
刊名	bioconjugate chemistry
	2012
卷号	23 期号:12 页码:2335-2343
关键词	POLYELECTROLYTE MULTILAYER FILMS POLYMER THERAPEUTICS TARGETED DELIVERY ANTICANCER DRUGS CLICK CAPSULES GROWTH REGIME CANCER CELLS NANOPARTICLES CISPLATIN TUMOR
ISSN号	1043-1802
通讯作者	meng fb
中文摘要	platinum(iv), a pro-drug of platinum(ii), was conjugated to poly(l-lysine) (pll), and then assembled with poly(glutamic acid) (pga) through a layer-by-layer (lbl) approach on colloidal silica templates. after removal of the templates, biodegradable pga/pll-pt(iv) multilayer capsules (diameter = 0.5 mu m) with 10 mu g of platinum incorporated into each bilayer were obtained. under acidic and/or reductive conditions, the amount and rate of platinum released from the capsules were increased, which are desirable traits for platinum-based anticancer drug delivery systems. furthermore, in vitro evaluation showed that the pga/pll-pt(iv) multilayer microcapsule's displayed higher cytotoxicity (ic50pt = 3.5 mu g/ml) against colon cancer cells ct-26 than that of free cisplatin (ic50pt = 8.6 mu g/ml). this enhanced cytotoxicity was attributed to the effective internalization of the capsules by the cancer cells, which was observed by confocal laser scanning microscopy (clsm) imaging.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000312429900003
公开日期	2013-03-17
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47805]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou DF,Xiao HH,Meng FB,et al. Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery[J]. bioconjugate chemistry,2012,23(12):2335-2343.
APA	Zhou DF.,Xiao HH.,Meng FB.,Zhou SY.,Guo JS.,...&Huang YB.(2012).Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery.bioconjugate chemistry,23(12),2335-2343.
MLA	Zhou DF,et al."Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery".bioconjugate chemistry 23.12(2012):2335-2343.