Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry: Synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release

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	Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry: Synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release
	Yuan WZ(袁伟忠) ; Li XF(李小菲) ; Gu SY(顾淑英) ; Cao AM(曹阿民) ; Ren J(任杰)
刊名	Polymer
	2011
卷号	52 期号:3 页码:658-666
ISSN号	0032-3861
其他题名	采用ROP, ATRP and click方法制备壳聚糖嵌端共聚物: 合成, 自组装, 温敏性和药物释放
通讯作者	袁伟忠
英文摘要	Novel amphiphilic chitosan-g-poly(epsilon-caprolactone)-(g-poly(2-(2-methoxyethoxy)ethyl methacrylate)co-oligo(ethylene glycol) methacrylate) (CS-g-PCL(-g-P(MEO(2)MA-co-OEGMA))) copolymers with double side chains of PCL and P(MEO(2)MA-co-OEGMA) were synthesized via combination of ring-opening polymerization (ROP), atom transfer radical polymerization (ATRP) and click chemistry. The molar ratio of PCL and P(MEO(2)MA-co-OEGMA) was varied through variation of the feed ratio and the coupling efficiency of click chemistry is comparatively high. The graft copolymers can assemble into spherical micelles. The micelles show thermosensitive properties and the lower critical solution temperatures (LCSTs) were influenced by CS chains and the ratio of PCL and P(MEO(2)MA-co-OEGMA) side chains. Moreover, the micelles can reversibly swell and shrink in response to the change of temperatures. Furthermore, the micelles present obvious fluorescence and the fluorescent intensity can be adjusted by altering the temperatures. The investigation of doxorubicin release from the micelles indicated that the release rate of the drug could be effectively controlled by altering the temperatures. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	高分子化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.polymer.2010.12.052
语种	英语
WOS记录号	WOS:000287013600011
公开日期	2013-03-07
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22960]
专题	上海有机化学研究所_高分子材料研究室
推荐引用方式 GB/T 7714	Yuan WZ,Li XF,Gu SY,et al. Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry: Synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release[J]. Polymer,2011,52(3):658-666.
APA	袁伟忠,李小菲,顾淑英,曹阿民,&任杰.(2011).Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry: Synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release.Polymer,52(3),658-666.
MLA	袁伟忠,et al."Amphiphilic chitosan graft copolymer via combination of ROP, ATRP and click chemistry: Synthesis, self-assembly, thermosensitivity, fluorescence, and controlled drug release".Polymer 52.3(2011):658-666.