A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps

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	A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps
	Li GJ(李贵杰) ; Wang EJ(王二娟) ; Chen HY(陈好益) ; Li HF(李宏峰) ; Liu YH(刘元红) ; Wang P(王鹏)
刊名	Tetrahedron
	2008
卷号	64 期号:38 页码:9033-9043
ISSN号	0040-4020
其他题名	偶联及Friedel-Crafts反应作为关键步骤的芴及含有噻吩或吲哚的杂环并茚类化合物的普适性合成
通讯作者	刘元红
英文摘要	A general and efficient synthesis of fluorenes or heterocycle-fused indenes including 3-thia-cyclopenta[a]indenes, 9-thia-indenol[1,2-a]indenes, 5,6-dihydroindeno[2,1-b]indoles has been developed. This methodology is realized by a multistep protocol. involving first preparation of ortho-formylbiaryls through Suzuki-Miyaura Coupling of o-bromobenzaldehydes with arylboronic acids or the coupling of aryl halides with 2-formylbenzene boronic acid, this is followed by Grignard addition and Friedel-Crafts cyclization reactions catalyzed by Bronsted or Lewis acid to form the desired fluorene or indene rings. The method offers several advantages such as high yields, high selectivities, mild reaction conditions, easily accessible starting materials, and so on. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题	有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tet.2008.07.021
语种	英语
WOS记录号	WOS:000259045100002
公开日期	2013-03-11
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/24259]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Li GJ,Wang EJ,Chen HY,et al. A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps[J]. Tetrahedron,2008,64(38):9033-9043.
APA	李贵杰,王二娟,陈好益,李宏峰,刘元红,&王鹏.(2008).A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps.Tetrahedron,64(38),9033-9043.
MLA	李贵杰,et al."A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps".Tetrahedron 64.38(2008):9033-9043.