Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes

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	Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes
	Zheng YT(郑永唐) ; Bi KL(贲昆龙) ; Jin SW(金善炜)
刊名	Acta Pharmacol. Sin.
	1999
卷号	20 期号:3 页码:239-243
ISSN号	1671-4083
其他题名	α库瓜子蛋白抑制急性感染而不抑制慢性感染T淋巴细胞中HIV－1的复制
通讯作者	贲昆龙
英文摘要	To identify the anti-human immunodeficiency virus type 1 (HIV-1) activities of α-momorcharin (α－MMC) from momordica charantia in acutely and chronically infected Tlymphocytes. METHODS: The anti-HIV activities of －MMC were examined by 1) the inhibition of syncytia formation inducedby HIV-1 ⅢB; 2) reduction of p24 core antigen expression level and decrease in numbers of HIV antigen positive cells in acutely and chronically infected cultures. The cytotoxic effects of α－MMC was tested by trypan blue dye exclusion or colorimetric MTT assay. RESULTS: α－MMC wasfound to obviously inhibit HIV-1 ⅢB-inducing C8166 syncytia formation and markedly reduced both expression of p24 core antigen and the numbers of HIV antigen positive cells in acutely but not chronically HIV-1-infected culture. The median effective concentration (EC=50) in these assays were 0.016, 0.07, and 0.32 mg.L^1, respectively. CONCLUSION: α-MMC is a unique component of momorcharin with anti-HIV activity, and markedly inhibited HIV-1replication in acutely but not chronically HIV-1-infected T-lymphocytes.
学科主题	生命有机化学
收录类别	SCI
语种	英语
WOS记录号	WOS:000079115400009
公开日期	2013-03-12
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/24709]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Zheng YT,Bi KL,Jin SW. Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes[J]. Acta Pharmacol. Sin.,1999,20(3):239-243.
APA	郑永唐,贲昆龙,&金善炜.(1999).Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes.Acta Pharmacol. Sin.,20(3),239-243.
MLA	郑永唐,et al."Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes".Acta Pharmacol. Sin. 20.3(1999):239-243.