Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide

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	Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide
	Zhu CY(朱纯银) ; Sun XL(孙秀丽) ; Deng XM(邓贤明) ; Zheng JC(郑君成) ; Tang Y(唐勇)
刊名	Tetrahedron
	2008
卷号	64 期号:23 页码:5583-5589
ISSN号	0040-4020
其他题名	Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide
通讯作者	唐勇
英文摘要	A protocol for the synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide are described. Sulfonium salt 1 reacts with substituted nitroalkenes smoothly to generate isoxazoline N-oxides in high to excellent yields with dr higher than 99/1. Its asymmetric version has been developed by using cinchona alkaloid-derived ammonium salts 6a and 6b instead of sulfonium salt 1 and higher than 96% ee values are achieved. This method has also been successfully applied to the formal synthesis of dehydroclausenamide. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题	有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tet.2008.03.075
语种	英语
WOS记录号	WOS:000256412800023
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19341]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Zhu CY,Sun XL,Deng XM,et al. Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide[J]. Tetrahedron,2008,64(23):5583-5589.
APA	朱纯银,孙秀丽,邓贤明,郑君成,&唐勇.(2008).Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide.Tetrahedron,64(23),5583-5589.
MLA	朱纯银,et al."Synthesis of isoxazoline N-oxides and its application in the formal synthesis of dehydroclausenamide".Tetrahedron 64.23(2008):5583-5589.