Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone | |
Zhou ZZ(周佐中) ; Suo D(索栋) ; Yang ZY(杨震宇) ; Chen L(陈琳) ; Hu TS(胡泰山) ; Yao ZJ(姚祝军) | |
刊名 | Chin. J. Chem.
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2009 | |
卷号 | 27期号:1页码:135-140 |
ISSN号 | 1001-604X |
其他题名 | 群蛀虫内酯C2-C10片断的立体选性合成 |
通讯作者 | 陈琳 ; 姚祝军 |
英文摘要 | A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished. starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-alpha-phenylethanamine was successfully employed as a key step to embed the isolated C8-methyl group with the correct absolute configuration (99% de). The C3-C4 cis-double bond was stereospecifically furnished by an RCM (ring-closing metathesis) approach. Fragment 13 contains all preset functionalities and will be a useful precursor for the convergent total synthesis of clavulactone. |
学科主题 | 生命有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1002/cjoc.200990006 |
语种 | 英语 |
WOS记录号 | WOS:000264039400023 |
公开日期 | 2013-02-26 |
内容类型 | 期刊论文 |
源URL | [http://202.127.28.38/handle/331003/21133] ![]() |
专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhou ZZ,Suo D,Yang ZY,et al. Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone[J]. Chin. J. Chem.,2009,27(1):135-140. |
APA | 周佐中,索栋,杨震宇,陈琳,胡泰山,&姚祝军.(2009).Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone.Chin. J. Chem.,27(1),135-140. |
MLA | 周佐中,et al."Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone".Chin. J. Chem. 27.1(2009):135-140. |
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