Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone

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	Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone
	Zhou ZZ(周佐中) ; Suo D(索栋) ; Yang ZY(杨震宇) ; Chen L(陈琳) ; Hu TS(胡泰山) ; Yao ZJ(姚祝军)
刊名	Chin. J. Chem.
	2009
卷号	27 期号:1 页码:135-140
ISSN号	1001-604X
其他题名	群蛀虫内酯C2-C10片断的立体选性合成
通讯作者	陈琳 ; 姚祝军
英文摘要	A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished. starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-alpha-phenylethanamine was successfully employed as a key step to embed the isolated C8-methyl group with the correct absolute configuration (99% de). The C3-C4 cis-double bond was stereospecifically furnished by an RCM (ring-closing metathesis) approach. Fragment 13 contains all preset functionalities and will be a useful precursor for the convergent total synthesis of clavulactone.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/cjoc.200990006
语种	英语
WOS记录号	WOS:000264039400023
公开日期	2013-02-26
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/21133]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Zhou ZZ,Suo D,Yang ZY,et al. Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone[J]. Chin. J. Chem.,2009,27(1):135-140.
APA	周佐中,索栋,杨震宇,陈琳,胡泰山,&姚祝军.(2009).Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone.Chin. J. Chem.,27(1),135-140.
MLA	周佐中,et al."Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone".Chin. J. Chem. 27.1(2009):135-140.