RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine

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	RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine
	Cong X(丛欣) ; Liao QJ(廖清江) ; Yao ZJ(姚祝军)
刊名	J. Org. Chem.
	2004
卷号	69 期号:16 页码:5314-5321
ISSN号	0022-3263
其他题名	从L-丝氨酸出发利用RCM方法非对映选择性合成反式邻二氨基环烷醇
通讯作者	姚祝军
英文摘要	Starting from L-serine, the asymmetric synthesis of four diaminocyclitol derivatives as sugar-based glycosidase inhibitors has been achieved using ring-closing metathesis (RCM) as a key step. Introduction of vicinal trans-diamino functionality onto the acyclic precursors was accomplished by highly diastereoselective addition of Grignard reagent to imine, and the elaboration of polyhydroxylic groups was effected via diastereoselective olefin epoxidation or dihydroxylation. The absolute configurations of final products were confirmed by 2D NMR studies.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jo0496547
语种	英语
WOS记录号	WOS:000223008100020
公开日期	2013-02-26
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/21049]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Cong X,Liao QJ,Yao ZJ. RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine[J]. J. Org. Chem.,2004,69(16):5314-5321.
APA	丛欣,廖清江,&姚祝军.(2004).RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine.J. Org. Chem.,69(16),5314-5321.
MLA	丛欣,et al."RCM approaches toward the diastereoselective synthesis of vicinal trans-diaminocyclitols from L-serine".J. Org. Chem. 69.16(2004):5314-5321.