Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity

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	Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity
	Li W(李微) ; DANG YONGJUN ; Liu J(刘钧) ; Yu B(俞飚)
刊名	Bioorg. Med. Chem. Lett.
	2010
卷号	20 期号:10 页码:3112-3115
ISSN号	0960-894X
其他题名	保持Hippuristanol的抗增殖活性所必须的裸缩酮的立体结构
通讯作者	刘钧 ; 俞飚
英文摘要	Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.bmcl.2010.03.093
语种	英语
WOS记录号	WOS:000277246300020
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19121]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Li W,DANG YONGJUN,Liu J,et al. Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity[J]. Bioorg. Med. Chem. Lett.,2010,20(10):3112-3115.
APA	李微,DANG YONGJUN,刘钧,&俞飚.(2010).Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.Bioorg. Med. Chem. Lett.,20(10),3112-3115.
MLA	李微,et al."Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity".Bioorg. Med. Chem. Lett. 20.10(2010):3112-3115.