Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity | |
Li W(李微) ; DANG YONGJUN ; Liu J(刘钧) ; Yu B(俞飚) | |
刊名 | Bioorg. Med. Chem. Lett.
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2010 | |
卷号 | 20期号:10页码:3112-3115 |
ISSN号 | 0960-894X |
其他题名 | 保持Hippuristanol的抗增殖活性所必须的裸缩酮的立体结构 |
通讯作者 | 刘钧 ; 俞飚 |
英文摘要 | Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity. (C) 2010 Elsevier Ltd. All rights reserved. |
学科主题 | 生命有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1016/j.bmcl.2010.03.093 |
语种 | 英语 |
WOS记录号 | WOS:000277246300020 |
公开日期 | 2013-02-25 |
内容类型 | 期刊论文 |
源URL | [http://202.127.28.38/handle/331003/19121] ![]() |
专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
推荐引用方式 GB/T 7714 | Li W,DANG YONGJUN,Liu J,et al. Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity[J]. Bioorg. Med. Chem. Lett.,2010,20(10):3112-3115. |
APA | 李微,DANG YONGJUN,刘钧,&俞飚.(2010).Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.Bioorg. Med. Chem. Lett.,20(10),3112-3115. |
MLA | 李微,et al."Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity".Bioorg. Med. Chem. Lett. 20.10(2010):3112-3115. |
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