Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases

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	Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases
	Yang Y(杨友) ; Li Y(李瑶) ; Yu B(俞飚)
刊名	J. Am. Chem. Soc.
	2009
卷号	131 期号:34 页码:12076-12077
ISSN号	0002-7863
其他题名	选择性的昆虫和真菌的β-N-乙酰氨基葡萄糖水解酶抑制剂TMG-chitotriomycin的全合成及结构修正
通讯作者	俞飚
英文摘要	TMG-chitotriomycin, a potent and selective inhibitor of the B-N-acetylglucosarninidases that possesses an unique N,N,N-trimethyl-D-glucosamine (TMG) residue, is revised to be the TMG-B-(1 -> 4)-chitotriose instead of the originally proposed alpha-anomer via its total synthesis, for which a highly convergent approach was developed in which the sterically demanding (1 -> 4)-glycosidic linkages are efficiently constructed by the Au(I)-catalyzed glycosylation protocol with glycosyl o-hexynylbenzoates as donors.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ja9055245
语种	英语
WOS记录号	WOS:000269379600028
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19095]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Yang Y,Li Y,Yu B. Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases[J]. J. Am. Chem. Soc.,2009,131(34):12076-12077.
APA	杨友,李瑶,&俞飚.(2009).Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases.J. Am. Chem. Soc.,131(34),12076-12077.
MLA	杨友,et al."Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases".J. Am. Chem. Soc. 131.34(2009):12076-12077.