4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones

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	4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones
	Li YW(李亚雯) ; Liu XY(刘心元) ; Yang YQ(杨映权) ; Zhao G(赵刚)
刊名	J. Org. Chem.
	2007
卷号	72 期号:1 页码:288-291
ISSN号	0022-3263
其他题名	4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones
通讯作者	赵刚
英文摘要	To seek novel metal-free organic catalysts for epoxidation with high stereoselectivity, a series of 4-substituted-alpha,alpha-diaryl-prolinols were synthesized in four steps from trans-4-hydroxyl-L-proline. These prolinol derivatives catalyzed the asymmetric epoxidation of alpha,beta-enones to give the corresponding chiral epoxides in good yields and high enantioselectivities under mild reaction conditions. Studies of substituent effects on enantioselectivity revealed that steric bulk and electronic effect promoted higher enantioselectivity, and prolinol 8a was found to be the best catalyst until now.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jo0617619
语种	英语
WOS记录号	WOS:000243156900040
公开日期	2013-02-26
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/20733]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Li YW,Liu XY,Yang YQ,et al. 4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones[J]. J. Org. Chem.,2007,72(1):288-291.
APA	李亚雯,刘心元,杨映权,&赵刚.(2007).4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones.J. Org. Chem.,72(1),288-291.
MLA	李亚雯,et al."4-Substituted-alpha,alpha-diaryl-prolinols improve the enantioselective catalytic epoxidation of alpha,beta-enones".J. Org. Chem. 72.1(2007):288-291.