Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine

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	Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine
	Wang GY(王广印) ; Liu XS(刘新顺) ; Zhao G(赵刚)
刊名	Tetrahedron-Asymmetry
	2005
卷号	16 期号:10 页码:1873-1879
ISSN号	0957-4166
其他题名	高分子负载手性磺酰胺催化一锅法还原β-羰基腈：一种合成(R)-氟西汀和度洛西汀使用的方法
通讯作者	赵刚
英文摘要	Enantioselective reduction of beta-keto nitriles to optically active 1,3-amino alcohols has been carried out in one Step using an excess of borane-dimethyl sulfide complex as a reductant and a polymer-supported chiral sulfonamide as a catalyst with moderate to high enantioselectivity. The facile and enantioselective method to prepare optically active 1,3-amino alcohols to be converted into 3-aryloxy-3-arylpropyl imiiie-type antidepressant drugs (R)-fluoxetine, and (R)-duloxetine is also reported. (C) 2005 Elsevier Ltd. All rights reserved.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetasy.2005.04.002
语种	英语
WOS记录号	WOS:000229529800019
公开日期	2013-02-26
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/20685]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Wang GY,Liu XS,Zhao G. Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine[J]. Tetrahedron-Asymmetry,2005,16(10):1873-1879.
APA	王广印,刘新顺,&赵刚.(2005).Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine.Tetrahedron-Asymmetry,16(10),1873-1879.
MLA	王广印,et al."Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine".Tetrahedron-Asymmetry 16.10(2005):1873-1879.