Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells

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	Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells
	Y. Zhang ; L. Ren ; M. Li ; X. Lin ; H. F. Zhao ; K. Yang
刊名	Journal of Materials Science & Technology
	2012
卷号	28 期号:9 页码:769-772
关键词	Magnesium Biodegradation Alkalinity Cancer cell
ISSN号	1005-0302
中文摘要	Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2+ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2+ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2+ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells.
原文出处	://WOS:000310178300001
公开日期	2013-02-05
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/60463]
专题	金属研究所_中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. Zhang,L. Ren,M. Li,et al. Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells[J]. Journal of Materials Science & Technology,2012,28(9):769-772.
APA	Y. Zhang,L. Ren,M. Li,X. Lin,H. F. Zhao,&K. Yang.(2012).Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells.Journal of Materials Science & Technology,28(9),769-772.
MLA	Y. Zhang,et al."Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells".Journal of Materials Science & Technology 28.9(2012):769-772.