Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal

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	Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
	Wang P(王平) ; Ma DW(马大为) ; J. Keski-Oja ; Pei DQ(裴端卿)
刊名	J. Biol. Chem.
	2004
卷号	279 期号:10 页码:9331-9336
ISSN号	0021-9258
其他题名	Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
通讯作者	裴端卿
英文摘要	Members of the membrane-type matrix metalloproteinases (MT-MMPs) have been implicated in a wide range of physiological and pathological processes from normal development to tumor growth. Tethered on plasma membrane, these enzymes are potentially regulated by the trafficking machinery of the cells. Here we demonstrate that both MT1-MMP and MT3-MMP are internalized, transported to the trans-Golgi network through early endosomes, and recycled back to cell surface in 60 min in a manner distinct from the one employed by transferrin receptor. Interestingly, co-expressed MT1-MMP and MT3-MMP are localized and routed in the same vesicles throughout the trafficking process. We further demonstrated that the carboxyl-terminal sequence DKV582 of MT1-MMP is required for its recycling, thus defining a novel recycling motif. These results suggest that MT-MMPs may coordinate their proteolytic activities through the cellular trafficking machinery.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1074/jbc.M312369200
语种	英语
WOS记录号	WOS:000189265900096
公开日期	2013-02-19
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/15469]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Wang P,Ma DW,J. Keski-Oja,et al. Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal[J]. J. Biol. Chem.,2004,279(10):9331-9336.
APA	王平,马大为,J. Keski-Oja,&裴端卿.(2004).Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal.J. Biol. Chem.,279(10),9331-9336.
MLA	王平,et al."Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal".J. Biol. Chem. 279.10(2004):9331-9336.