Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone

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	Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone
	Liu KG(刘克刚) ; Yan S(闫石) ; Wu YL(吴毓林) ; Yao ZJ(姚祝军)
刊名	Org. Lett.
	2004
卷号	6 期号:13 页码:2269-2272
ISSN号	1523-7060
其他题名	从葡萄糖酸内酯出发合成流感药物GG167的关键中间体4-Azido-4-deoxy-Neu5,7,8,9Ac42en1Me
通讯作者	姚祝军
英文摘要	[GRAPHICS] Stereoselective synthesis of 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glyc ero-D-galacto-non-2-enonic acid methyl ester, an advanced key intermediate for the synthesis of neuraminidase inhibitor GG167 (Zanamivir, Relenza), was accomplished using d-glucono-delta-lactone as starting material. A highly diastereoselective allyllation of an imine intermediate, a regioselective azide-opening of an aziridine, and chemoselective oxidations of vicinal diols served successfully as key steps.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ol0491890
语种	英语
WOS记录号	WOS:000222119400048
公开日期	2013-01-17
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/14084]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Liu KG,Yan S,Wu YL,et al. Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone[J]. Org. Lett.,2004,6(13):2269-2272.
APA	刘克刚,闫石,吴毓林,&姚祝军.(2004).Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone.Org. Lett.,6(13),2269-2272.
MLA	刘克刚,et al."Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone".Org. Lett. 6.13(2004):2269-2272.