Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone | |
Liu KG(刘克刚) ; Yan S(闫石) ; Wu YL(吴毓林) ; Yao ZJ(姚祝军) | |
刊名 | Org. Lett.
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2004 | |
卷号 | 6期号:13页码:2269-2272 |
ISSN号 | 1523-7060 |
其他题名 | 从葡萄糖酸内酯出发合成流感药物GG167的关键中间体4-Azido-4-deoxy-Neu5,7,8,9Ac42en1Me |
通讯作者 | 姚祝军 |
英文摘要 | [GRAPHICS] Stereoselective synthesis of 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glyc ero-D-galacto-non-2-enonic acid methyl ester, an advanced key intermediate for the synthesis of neuraminidase inhibitor GG167 (Zanamivir, Relenza), was accomplished using d-glucono-delta-lactone as starting material. A highly diastereoselective allyllation of an imine intermediate, a regioselective azide-opening of an aziridine, and chemoselective oxidations of vicinal diols served successfully as key steps. |
学科主题 | 生命有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1021/ol0491890 |
语种 | 英语 |
WOS记录号 | WOS:000222119400048 |
公开日期 | 2013-01-17 |
内容类型 | 期刊论文 |
源URL | [http://202.127.28.38/handle/331003/14084] ![]() |
专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
推荐引用方式 GB/T 7714 | Liu KG,Yan S,Wu YL,et al. Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone[J]. Org. Lett.,2004,6(13):2269-2272. |
APA | 刘克刚,闫石,吴毓林,&姚祝军.(2004).Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone.Org. Lett.,6(13),2269-2272. |
MLA | 刘克刚,et al."Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac(4)2en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone".Org. Lett. 6.13(2004):2269-2272. |
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