Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations

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	Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations
	Wang PY(王鹏远) ; Song LP(宋力平) ; Yi H(易海) ; Zhang M(张敏) ; Zhu SZ(朱仕正) ; Deng HM(邓红梅) ; Shao M(邵敏)
刊名	Tetrahedron Lett.
	2010
卷号	51 期号:30 页码:3975-3977
ISSN号	0040-4039
其他题名	简便的一步法合成氟取代二氢吡喃衍生物及其进一步化学转化
通讯作者	宋力平 ; 朱仕正
英文摘要	One-pot four-component reactions of aromatic aldehyde, Meldrum's acid, ethyl-4,4,4-trifluoro-1,3-dioxobutanoate, and ammonium acetate afford ethyl 2-hydroxy-6-oxo-4-aryl-2-(trifluoromethyl)piperidine-3-carboxylate in good yields. The one-pot four-component process consists of an initial Michael addition, and a subsequent intramolecular cyclization. The effect of solvents on the reaction efficiency and yield is briefly investigated. The structure of product is further confirmed by XRD analysis. Meanwhile, the further transformation of hemi-aminal moiety to the corresponding dehydrated product is also achieved under the mild reaction conditions. The possible mechanism for the formation of product is presented. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	有机氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetlet.2010.05.110
语种	英语
WOS记录号	WOS:000279817400029
公开日期	2013-01-18
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/14488]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Wang PY,Song LP,Yi H,et al. Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations[J]. Tetrahedron Lett.,2010,51(30):3975-3977.
APA	王鹏远.,宋力平.,易海.,张敏.,朱仕正.,...&邵敏.(2010).Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations.Tetrahedron Lett.,51(30),3975-3977.
MLA	王鹏远,et al."Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations".Tetrahedron Lett. 51.30(2010):3975-3977.