Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 中科院天然产物有机化学重点实验室

	Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media
	YU HUILEI ; Xu JH(许建和) ; WANG YUXIAO ; Lu WY(卢文芽) ; Lin GQ(林国强)
刊名	J. Comb. Chem.
	2008
卷号	10 期号:1 页码:79-87
ISSN号	1520-4766
其他题名	Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media
通讯作者	许建和
英文摘要	Glycoconjugates can be artificially synthesized by combinatorial biocatalysis. An example is given in this paper describing the construction of glycoconjugates array by using glycosidase and lipase in nonaqueous media. This array was started from glucose, with three aryl alcohols as the aglycone moiety of glycosides and five acids or esters as acyl donors for combinatorial acylation of glycosides, affording a three-dimensional array containing about 30 members with diverse structures. The array would be more abundant if more aglycones and acyl donors with other structures were filled in. Indeed, diverse classes of carbohydrates besides glucose can also be employed for generating diverse glycoconjugates due to their different roles in numerous physiological responses. The composition and distribution of the demonstration glycoconjugates array was detected and evaluated by HPLC-MS with electrospray ionization. And also, the distribution of the artificial array can be adjusted by changing the molar ratio of the auxiliary materials.
学科主题	天然产物有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/cc7001606
语种	英语
WOS记录号	WOS:000252409800013
公开日期	2013-02-20
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/16685]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	YU HUILEI,Xu JH,WANG YUXIAO,et al. Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media[J]. J. Comb. Chem.,2008,10(1):79-87.
APA	YU HUILEI,许建和,WANG YUXIAO,卢文芽,&林国强.(2008).Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media.J. Comb. Chem.,10(1),79-87.
MLA	YU HUILEI,et al."Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media".J. Comb. Chem. 10.1(2008):79-87.