Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch

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	Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
	Zhu J(朱静) ; Tong XT(童孝田) ; Cao CY(曹春阳) ; Wu G(吴宫) ; Zhang NX(张乃霞) ; Wu HM(吴厚铭)
刊名	Biochem. Biophys. Res. Commun.
	2010
卷号	391 期号:1 页码:627-633
ISSN号	0006-291X
其他题名	Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
通讯作者	吴厚铭
英文摘要	The solution structure of BmK alpha Tx11 presented by this paper is distinctive from any other structures of wide-type scorpion alpha-toxins reported so far, for its trans-9,10 peptide bond conformation is accompanied by 'protruding' topology of the 'NC-domain'. The orientation of the C-tail of BmK alpha Tx11 is obviously different from that of classical alpha-toxins (e g., AaH2, BmK-M8), despite the fact that they share common trans conformation of peptide bond between residues 9 and 10 Accordingly, there must be other structural factors dominating the orientation of the C-tail except the conformation of peptide bond 9-10. Our study reveals that residues at position 58 play an important role in it, and different type of residues at this position (e g.. Lys. Arg, Met, Ile) result in different spatial relationship between the C-terminus and the 'five-residue-turn' and then different topology of the 'NC-domain', therefore residues at position 58 are believed to function as structure and bioactivity switch for specificity of scorpion alpha-toxins The mechanism for stabilizing the geometry of the 'NC-domain' in wide-type scorpion alpha-toxins is also discussed (C) 2009 Elsevier Inc. All rights reserved
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.bbrc.2009.11.110
语种	英语
WOS记录号	WOS:000273624500110
公开日期	2013-02-21
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/17399]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Zhu J,Tong XT,Cao CY,et al. Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch[J]. Biochem. Biophys. Res. Commun.,2010,391(1):627-633.
APA	朱静,童孝田,曹春阳,吴宫,张乃霞,&吴厚铭.(2010).Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch.Biochem. Biophys. Res. Commun.,391(1),627-633.
MLA	朱静,et al."Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch".Biochem. Biophys. Res. Commun. 391.1(2010):627-633.